To allow for complete control of the application configuration, GO! Sync Mapbook uses reflection to load all of it’s components. This seems to cause a problem in Vista with machines that have Data Execution Prevention (DEP) running. The ActiveX controls that makeup ArcGIS Engine do not load properly.

There is a pretty good article here that shows how to turn it off completely.

I used the following command line to fix it:

bcdedit /set nx AlwaysOff

You need to run the command prompt as Administrator for it to work.